{"id":1335,"date":"2020-11-15T23:00:18","date_gmt":"2020-11-15T14:00:18","guid":{"rendered":"https:\/\/kokoro-hino.tokyo\/?p=1335"},"modified":"2020-11-15T23:00:18","modified_gmt":"2020-11-15T14:00:18","slug":"%e3%83%ac%e3%82%ad%e3%82%b5%e3%83%ab%e3%83%86%e3%82%a3%ef%bc%88%e3%83%96%e3%83%ac%e3%82%af%e3%82%b9%e3%83%94%e3%83%97%e3%83%a9%e3%82%be%e3%83%bc%e3%83%ab%ef%bc%89","status":"publish","type":"post","link":"https:\/\/kokoro-hino.tokyo\/?p=1335","title":{"rendered":"\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\uff08\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\uff09"},"content":{"rendered":"<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u30012006\u5e74\u306b\u5927\u585a\u88fd\u85ac\u304c\u898b\u3044\u3060\u3057\u305f\u56fd\u7523\u306e\u975e\u5b9a\u578b\u6297\u7cbe\u795e\u75c5\u85ac\u3067\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u5927\u585a\u88fd\u85ac\u3092\u5de8\u5927\u4f01\u696d\u306b\u5909\u8eab\u3055\u305b\u305f\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u306e\u5f8c\u7d99\u85ac\u3067\u3042\u308a\u3001\u56fd\u5185\u3067\u306f\u5927\u585a\u88fd\u85ac\u304c\u3001\u6d77\u5916\u3067\u306f\u5927\u585a\u88fd\u85ac\u3068\u30eb\u30f3\u30c9\u30d9\u30c3\u30af\u304c\u958b\u767a\u306b\u5f53\u305f\u308a\u3001\u5e02\u5834\u5c0e\u5165\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u767a\u58f2\u5f53\u6642\u5927\u585a\u88fd\u85ac\u306eMR\u304b\u3089\u3001\u300c\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u300d\u3068\u3044\u3046\u4e00\u822c\u540d\u306f\u3001\u300c\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\uff08\u969c\u5bb3\u3092\u7a81\u7834\u3059\u308b\uff09\u300d\u306b\u639b\u3051\u3066\u3044\u308b\u3068\u805e\u3044\u305f\u3053\u3068\u3092\u899a\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u672c\u90a6\u3067\u306e\u9069\u5fdc\u306f\u7d71\u5408\u5931\u8abf\u75c7\u3067\u3059\u3002\u7c73\u56fd\u3067\u306f\u7d71\u5408\u5931\u8abf\u75c7\u306e\u6cbb\u7642\u85ac\u3001\u304a\u3088\u3073\u3001\u3046\u3064\u75c5\u306e\u6cbb\u7642\u88dc\u52a9\u85ac\u3068\u3057\u3066FDA\u306b\u627f\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u5438\u53ce\u306f\u3001\u98df\u4e8b\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u305b\u3093\u3002\u98df\u5f8c\u306e\u670d\u7528\u3082\u98df\u524d\u3084\u7720\u524d\u306e\u670d\u7528\u3082\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u80c3\u9178\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u3002\u80c3\u9178\u3092\u6291\u3048\u308b\u30aa\u30e1\u30d7\u30e9\u30be\u30fc\u30eb\uff08PPI\uff09\u3068\u306e\u4f75\u7528\u306f\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u5438\u53ce\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u305b\u3093\u304c\u3001\u52b9\u679c\u306f\u5f37\u304f\u51fa\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\uff08\u30aa\u30e1\u30d7\u30e9\u30be\u30fc\u30eb 40 mg \u3068\u306e\u4f75\u7528\u3067 AUC \u304c22%\u5897\u52a0\uff09<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u7d71\u5408\u5931\u8abf\u75c7\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u306b\u3064\u3044\u3066\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u3068\u6bd4\u8f03\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u308c\u306b\u3088\u308b\u3068\u3001\u6709\u52b9\u6027\u306f\u540c\u7b49\u3001\u4f53\u91cd\u5897\u52a0\u7387\u3082\u307b\u307c\u540c\u3058\u3067\u3057\u305f\u304c\u3001\u30a2\u30ab\u30b7\u30b8\u30a2\u306e\u767a\u751f\u7387\u304c\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u3067\u4f4e\u304b\u3063\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u4f53\u91cd\u5897\u52a0\u306b\u3064\u3044\u3066\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u3068\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u6295\u4e0e52\u9031\u6642\u70b9\u3067\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u304c\u5e73\u5747 3.2 kg\u3001\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u304c\u5e73\u5747 4.0 kg \u306e\u4f53\u91cd\u5897\u52a0\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u307e\u305f\u3001\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u3068\u30e9\u30c4\u30fc\u30c0\uff08\u30eb\u30e9\u30b7\u30c9\u30f3\uff09\u3092\u6bd4\u8f03\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u7d71\u5408\u5931\u8abf\u75c7\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u306f\u540c\u7b49\u3067\u3042\u3063\u305f\u3082\u306e\u306e\u3001\u4f53\u91cd\u5897\u52a0\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u306b\u3064\u3044\u3066\u306f\u3001\u30e9\u30c4\u30fc\u30c0\u304c\u512a\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong><span style=\"font-family: 'arial black', sans-serif;\">\u4f5c\u7528\u6a5f\u5e8f<\/span><\/strong><\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u3001<strong><span style=\"font-family: 'arial black', sans-serif;\">\u30bb\u30ed\u30c8\u30cb\u30f31A\u53d7\u5bb9\u4f53<\/span><\/strong>\uff085-HT1A\u53d7\u5bb9\u4f53\uff09\u306e\u90e8\u5206\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u90e8\u5206\u30a2\u30b4\u30cb\u30b9\u30c8\u306f\u3001\u7d50\u5408\u3057\u305f\u53d7\u5bb9\u4f53\u306b\u5bfe\u3057\u3066\u906e\u65ad\u3068\u523a\u6fc0\u306e\u4e21\u65b9\u306e\u4f5c\u7528\u3092\u53ca\u307c\u3057\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u906e\u65ad\u3068\u523a\u6fc0\u306e\u6bd4\u7387\u306f\u56fa\u6709\u6d3b\u6027\u3068\u3057\u3066\u8868\u73fe\u3055\u308c\u3001\u81e8\u5e8a\u7684\u52b9\u679c\u3092\u6c7a\u5b9a\u3059\u308b\u3082\u306e\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u30bb\u30ed\u30c8\u30cb\u30f31A\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u306e\u52b9\u679c\u306f\u3001\u9059\u304b\u306b\u5f37\u3044\u3082\u306e\u3067\u3059\u3002<br \/>\n\uff08\u7d50\u5408\u89aa\u548c\u6027\u3082\u56fa\u6709\u6d3b\u6027\u3082\uff09<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u3001<strong><span style=\"font-family: 'arial black', sans-serif;\">\u30c9\u30fc\u30d1\u30df\u30f3D2\u53d7\u5bb9\u4f53<\/span><\/strong>\u306e\u90e8\u5206\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u30c9\u30fc\u30d1\u30df\u30f3D2\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u306e\u52b9\u679c\u306f\u3001\u5f31\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\uff08\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u306e\u56fa\u6709\u6d3b\u602760%\u306b\u5bfe\u3057\u3066\u30ec\u30ad\u30b5\u30eb\u30c6\u30a345\uff05\uff09<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u56fa\u6709\u6d3b\u6027\u304c\u4f4e\u3044\u5206\u3001\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u306b\u6bd4\u3079\u3066\u30a2\u30ab\u30b7\u30b8\u30a2\u306e\u51fa\u73fe\u304c\u5c11\u306a\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u3001<strong><span style=\"font-family: 'arial black', sans-serif;\">\u30bb\u30ed\u30c8\u30cb\u30f32A\u53d7\u5bb9\u4f53<\/span><\/strong>\uff085-HT2A\u53d7\u5bb9\u4f53\uff09\u306e\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\uff08\u62ee\u6297\u85ac\uff09\u3068\u3057\u3066\u4f5c\u7528\u3057\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306e\u30bb\u30ed\u30c8\u30cb\u30f32A\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u306e\u52b9\u679c\u306f\u3001\u5f37\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u3001\u4e3b\u306bCYP3A4 \u3068 CYP2D6\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u307e\u3059\u3002\u4ee3\u8b1d\u7269\u306f\u6d3b\u6027\u3092\u6301\u3061\u307e\u305b\u3093\u3002<\/p>\n<p class=\"has-background has-very-light-gray-background-color\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u3001\u7720\u6c17\u3084\u30a2\u30ab\u30b7\u30b8\u30a2\u3067\u30a8\u30d3\u30ea\u30d5\u30a1\u30a4\u304c\u4f7f\u3048\u306a\u304b\u3063\u305f\u4eba\u306b\u3068\u3063\u3066\u3001\u6709\u671b\u306a\u9078\u629e\u80a2\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>\uff08\u4ee5\u4e0b\u306fIF\u306a\u3069\u3092\u53c2\u8003\u306b\u3057\u3066\u3044\u307e\u3059\uff09<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u9320<\/span><\/strong><\/span> 1 mg \/ \u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u9320 2 mg \/ REXULTI<br \/>\n\u4e00 \u822c \u540d\uff1a\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb \/ Brexpiprazole<\/p>\n<p>\u88fd\u9020\u8ca9\u58f2\u5143\uff1a\u5927\u585a\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e<\/p>\n<p>\u69cb\u9020\u5f0f<br \/>\n<img loading=\"lazy\" class=\"alignnone size-full wp-image-1368\" src=\"http:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-10-31-17_29_08-Window.jpg\" alt=\"\" width=\"\" height=\"\" srcset=\"https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-10-31-17_29_08-Window.jpg 783w, https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-10-31-17_29_08-Window-300x94.jpg 300w, https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-10-31-17_29_08-Window-768x240.jpg 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><\/p>\n<p><img loading=\"lazy\" class=\"alignnone size-full wp-image-1369\" src=\"http:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_21_07-Window.jpg\" alt=\"\" width=\"\" height=\"\" srcset=\"https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_21_07-Window.jpg 600w, https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_21_07-Window-197x300.jpg 197w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u52b9\u80fd\u53c8\u306f\u52b9\u679c<\/span><\/strong><\/span><br \/>\n\u7d71\u5408\u5931\u8abf\u75c7<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u7528\u6cd5\u53ca\u3073\u7528\u91cf<\/span><\/strong><\/span><br \/>\n\u901a\u5e38\u3001\u6210\u4eba\u306b\u306f\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u3068\u3057\u3066 1 \u65e5 1 \u56de 1 \u338e\u304b\u3089\u6295\u4e0e\u3092\u958b\u59cb\u3057\u305f\u5f8c\u30014 \u65e5\u4ee5\u4e0a\u306e\u9593\u9694\u3092\u3042\u3051\u3066\u5897\u91cf\u3057\u30011 \u65e5 1 \u56de 2 mg \u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3002<\/p>\n<p>\u672c\u5264\u3068 CYP2D6 \u963b\u5bb3\u5264\uff08\u30ad\u30cb\u30b8\u30f3\u3001<span style=\"color: #ff0000;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30d1\u30ed\u30ad\u30bb\u30c1\u30f3<\/span><\/strong><\/span>\u7b49\uff09\u53ca\u3073\/\u53c8\u306f\u5f37\u3044 CYP3A4 \u963b\u5bb3\u5264\uff08\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\u3001<span style=\"color: #ff0000;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3<\/span><\/strong><\/span>\u7b49\uff09\u3092\u4f75\u7528\u3059\u308b\u5834\u5408\u53ca\u3073 CYP2D6 \u306e\u6d3b\u6027\u304c\u6b20\u640d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u3066\u3044\u308b\u60a3\u8005\uff08Poor Metabolizer\uff09\u3067\u306f\u3001\u672c\u5264\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u305f\u3081\u3001\u4ee5\u4e0b\u306e\u8868\u3092\u53c2\u8003\u306b\u7528\u6cd5\u53ca\u3073\u7528\u91cf\u306e\u8abf\u7bc0\u3092\u884c\u3046\u3053\u3068\u3002<br \/>\n<img loading=\"lazy\" class=\"alignnone size-full wp-image-1370\" src=\"http:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_28_25-Window.jpg\" alt=\"\" width=\"\" height=\"\" srcset=\"https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_28_25-Window.jpg 855w, https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_28_25-Window-300x116.jpg 300w, https:\/\/kokoro-hino.tokyo\/wp-content\/uploads\/2020\/11\/2020-11-15-19_28_25-Window-768x298.jpg 768w\" sizes=\"(max-width: 855px) 100vw, 855px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">QT\/QTc \u8a55\u4fa1\u8a66\u9a13<\/span><\/strong><\/span><br \/>\n\u7d71\u5408\u5931\u8abf\u75c7\uff0f\u7d71\u5408\u5931\u8abf\u611f\u60c5\u969c\u5bb3\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u30014 mg \u53c8\u306f 12 mg \u306e\u7528\u91cf\u306b\u304a\u3051\u308b\u30d6\u30ec\u30af\u30b9\u30d4\u30d7\u30e9\u30be\u30fc\u30eb\u306e QTc \u9593\u9694\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8a55\u4fa1\u3057\u305f\u8a66\u9a13\u3067\u306f\u3001QTc \u9593\u9694\u306e\u5ef6\u9577\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u7d50\u5408\u89aa\u548c\u6027<\/span><\/strong><\/span>\u3000[Ki\u5024(nmol\/L)]<\/p>\n<p>5-HT 1A \u53d7\u5bb9\u4f53 0.12<br \/>\n\u03b1 1B \u53d7\u5bb9\u4f53 0.17<br \/>\n<strong><span style=\"font-family: 'arial black', sans-serif;\">D 2L \u53d7\u5bb9\u4f53 0.30<\/span><\/strong><br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n5-HT 2A \u53d7\u5bb9\u4f53 0.47<br \/>\n\u03b1 2C \u53d7\u5bb9\u4f53 0.59<br \/>\n<strong><span style=\"font-family: 'arial black', sans-serif;\">D 3 \u53d7\u5bb9\u4f53 1.1<\/span><\/strong><br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\n5-HT 2B \u53d7\u5bb9\u4f53 1.9<br \/>\n\u03b1 1D \u53d7\u5bb9\u4f53 2.6<br \/>\n5-HT 7 \u53d7\u5bb9\u4f53 3.7<br \/>\n\u03b1 1A \u53d7\u5bb9\u4f53 3.8<br \/>\nD 4 \u53d7\u5bb9\u4f53 6.3<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nH 1 \u53d7\u5bb9\u4f53 19<br \/>\n5-HT 2C \u53d7\u5bb9\u4f53 34<br \/>\n&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br \/>\nM 1 \u53d7\u5bb9\u4f53 \uff1e1,000\u2021<br \/>\nM 2 \u53d7\u5bb9\u4f53 \uff1e1,000\u2021<\/p>\n<p><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30bb\u30ed\u30c8\u30cb\u30f3 5-HT1 A \u53d7\u5bb9\u4f53\u90e8\u5206\u30a2\u30b4\u30cb\u30b9\u30c8\u4f5c\u7528<\/span><\/strong><\/p>\n<p><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30bb\u30ed\u30c8\u30cb\u30f3 5-HT 2A \u53d7\u5bb9\u4f53\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u4f5c\u7528<\/span><\/strong><\/p>\n<p><strong><span style=\"font-family: 'arial black', sans-serif;\">\u30c9\u30d1\u30df\u30f3 D 2 \u53d7\u5bb9\u4f53\u90e8\u5206\u30a2\u30b4\u30cb\u30b9\u30c8\u4f5c\u7528<\/span><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u8840\u4e2d\u6fc3\u5ea6\u306e\u63a8\u79fb<\/span><\/strong><\/span><br \/>\n<span style=\"color: #800000;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u5358\u56de\u6295\u4e0e<\/span><\/strong><\/span><br \/>\n\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u30006\u6642\u9593\u3001\u534a\u6e1b\u671f\u300053\uff5e67 \u6642\u9593<\/p>\n<p><span style=\"color: #800000;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u53cd\u5fa9\u6295\u4e0e<\/span><\/strong><\/span><br \/>\n\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u30004\u6642\u9593\u3001\u534a\u6e1b\u671f\u300092 \u6642\u9593<br \/>\n\u6295\u4e0e 10 \u65e5\u3067\u5b9a\u5e38\u72b6\u614b\u306b\u5230\u9054\u3059\u308b<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u7981\u5fcc<\/span><\/strong><\/span>\uff08\u6b21\u306e\u60a3\u8005\u306b\u306f\u6295\u4e0e\u3057\u306a\u3044\u3053\u3068\uff09<br \/>\n\u660f\u7761\u72b6\u614b\u306e\u60a3\u8005\uff3b\u660f\u7761\u72b6\u614b\u3092\u60aa\u5316\u3055\u305b\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002\uff3d<br \/>\n\u30d0\u30eb\u30d3\u30c4\u30fc\u30eb\u9178\u8a98\u5c0e\u4f53\u30fb\u9ebb\u9154\u5264\u7b49\u306e\u4e2d\u67a2\u795e\u7d4c\u6291\u5236\u5264\u306e\u5f37\u3044\u5f71\u97ff\u4e0b\u306b\u3042\u308b\u60a3\u8005\uff3b\u4e2d\u67a2\u795e\u7d4c\u6291\u5236\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3002\uff3d<br \/>\n\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3092\u6295\u4e0e\u4e2d\u306e\u60a3\u8005\uff08\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3092\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306e\u6551\u6025\u6cbb\u7642\u306b\u4f7f\u7528\u3059\u308b\u5834\u5408\u3092\u9664\u304f\uff09<br \/>\n\u672c\u5264\u306e\u6210\u5206\u306b\u5bfe\u3057\u904e\u654f\u75c7\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u60a3\u8005<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u91cd\u8981\u306a\u57fa\u672c\u7684\u6ce8\u610f<\/span><\/strong><\/span><br \/>\n\u7720\u6c17\u3001\u6ce8\u610f\u529b\u30fb\u96c6\u4e2d\u529b\u30fb\u53cd\u5c04\u904b\u52d5\u80fd\u529b\u7b49\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3001\u672c\u5264\u6295\u4e0e\u4e2d\u306e\u60a3\u8005\u306b\u306f\u81ea\u52d5\u8eca\u306e\u904b\u8ee2\u7b49\u5371\u967a\u3092\u4f34\u3046\u6a5f\u68b0\u306e\u64cd\u4f5c\u306b\u5f93\u4e8b\u3055\u305b\u306a\u3044\u3088\u3046\u6ce8\u610f\u3059\u308b\u3053\u3068\u3002<\/p>\n<p>\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u4f7f\u7528\u4e2d\u306b\u7279\u306b\u8ced\u535a\u306b\u5bfe\u3059\u308b\u6fc0\u3057\u3044\u885d\u52d5\u3092\u767a\u73fe\u3057\u305f\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u885d\u52d5\u3092\u5236\u5fa1\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u5916\u56fd\u306e\u88fd\u9020\u8ca9\u58f2\u5f8c\u306e\u5831\u544a\u306b\u3088\u308a\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8ced\u535a\u3088\u308a\u3082\u983b\u5ea6\u306f\u4f4e\u3044\u3067\u3059\u304c\u3001\u885d\u52d5\u7684\u3067\u5f37\u8feb\u7684\u306a\u6027\u8cea\u306e\u5236\u5fa1\u4e0d\u80fd\u306a\u6027\u884c\u52d5\u3001\u6d88\u8cbb\u884c\u52d5\u3001\u66b4\u98df\u30fb\u904e\u98df\u306a\u3069\u306e\u4ed6\u306e\u885d\u52d5\u306e\u5831\u544a\u3082\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u672c\u5264\u306e\u6295\u4e0e\u306b\u3088\u308a\u4f53\u91cd\u5897\u52a0\u53ca\u3073\u8102\u8cea\u7570\u5e38\u75c7\u306a\u3069\u306e\u4ee3\u8b1d\u306e\u5909\u5316\u304c\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3001\u672c\u5264\u6295\u4e0e\u4e2d\u306f\u4f53\u91cd\u306e\u63a8\u79fb\u3092\u6ce8\u610f\u6df1\u304f\u89b3\u5bdf\u3057\u3001\u4f53\u91cd\u306e\u5909\u52d5\u304c\u8a8d\u3081\u3089\u308c\u305f\u5834\u5408\u306b\u306f\u539f\u56e0\u7cbe\u67fb\uff08\u5408\u4f75\u75c7\u306e\u5f71\u97ff\u306e\u6709\u7121\u7b49\uff09\u3092\u5b9f\u65bd\u3057\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u9069\u5207\u306a\u51e6\u7f6e\u3092\u884c\u3046\u3053\u3068\u3002<\/p>\n<p>\u56a5\u4e0b\u969c\u5bb3\u304c\u767a\u73fe\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u306e\u3067\u3001\u7279\u306b\u8aa4\u56a5\u6027\u80ba\u708e\u306e\u30ea\u30b9\u30af\u306e\u3042\u308b\u60a3\u8005\u306b\u672c\u5264\u3092\u6295\u4e0e\u3059\u308b\u5834\u5408\u306b\u306f\u3001\u614e\u91cd\u306b\u7d4c\u904e\u3092\u89b3\u5bdf\u3059\u308b\u3053\u3068\u3002<\/p>\n<p>\u6295\u4e0e\u521d\u671f\u3001\u518d\u6295\u4e0e\u6642\u3001\u5897\u91cf\u6642\u306b\u03b1\u4ea4\u611f\u795e\u7d4c\u906e\u65ad\u4f5c\u7528\u306b\u57fa\u3065\u304f\u8d77\u7acb\u6027\u4f4e\u8840\u5727\u304c\u3042\u3089\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3001\u60a3\u8005\u306e\u72b6\u614b\u3092\u614e\u91cd\u306b\u89b3\u5bdf\u3057\u3001\u4f4e\u8840\u5727\u75c7\u72b6\u304c\u3042\u3089\u308f\u308c\u305f\u5834\u5408\u306f\u6e1b\u91cf\u3059\u308b\u7b49\u3001\u9069\u5207\u306a\u51e6\u7f6e\u3092\u884c\u3046\u3053\u3068\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u91cd\u5927\u306a\u526f\u4f5c\u7528<\/span><\/strong><\/span><br \/>\n\u60aa\u6027\u75c7\u5019\u7fa4\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u9045\u767a\u6027\u30b8\u30b9\u30ad\u30cd\u30b8\u30a2\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u9ebb\u75fa\u6027\u30a4\u30ec\u30a6\u30b9\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u6a2a\u7d0b\u7b4b\u878d\u89e3\u75c7\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u9ad8\u8840\u7cd6\uff080.1%\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u30b1\u30c8\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u660f\u7761\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u75d9\u6523\uff080.1%\uff09\u3001\u7121\u9846\u7c92\u7403\u75c7\uff08\u983b\u5ea6\u4e0d\u660e\uff09\u3001\u767d\u8840\u7403\u6e1b\u5c11\uff080.1%\uff09\u80ba\u585e\u6813\u75c7\uff080.1\uff05\uff09\u3001\u6df1\u90e8\u9759\u8108\u8840\u6813\u75c7\uff080.1\uff05\uff09<\/p>\n<p><span style=\"color: #0000ff;\"><strong><span style=\"font-family: 'arial black', sans-serif;\">\u305d\u306e\u4ed6\u306e\u526f\u4f5c\u7528<\/span><\/strong><\/span>\uff081\uff05\u4ee5\u4e0a\u306e\u3082\u306e\u3001\u75c7\u4f8b\u6570 1,520\uff09<br \/>\n\u30a2\u30ab\u30b7\u30b8\u30a2 78 (5.1)<br \/>\n\u4e0d\u7720\u75c7 68 (4.5)<br \/>\n\u982d\u75db 68 (4.5)<br \/>\n\u632f\u6226 43 (2.8)<br \/>\n\u50be\u7720 30 (2.0)<br \/>\n\u6fc0\u8d8a 28 (1.8)<br \/>\n\u9310\u4f53\u5916\u8def\u969c\u5bb3 28 (1.8)<br \/>\n\u60aa\u5fc3 28 (1.8)<br \/>\n\u4fbf\u79d8 28 (1.8)<br \/>\n\u6d6e\u52d5\u6027\u3081\u307e\u3044 21 (1.4)<br \/>\n\u93ae\u9759 17 (1.1)<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30ec\u30ad\u30b5\u30eb\u30c6\u30a3\u306f\u30012006\u5e74\u306b\u5927\u585a\u88fd\u85ac\u304c\u898b\u3044\u3060\u3057\u305f\u56fd\u7523\u306e\u975e\u5b9a\u578b\u6297\u7cbe\u795e\u75c5\u85ac\u3067\u3059\u3002 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