{"id":814,"date":"2020-06-23T14:45:42","date_gmt":"2020-06-23T05:45:42","guid":{"rendered":"https:\/\/kokoro-hino.tokyo\/?p=814"},"modified":"2020-08-06T21:58:39","modified_gmt":"2020-08-06T12:58:39","slug":"%e3%83%a9%e3%83%84%e3%83%bc%e3%83%80%ef%bc%88%e3%83%ab%e3%83%a9%e3%82%b7%e3%83%89%e3%83%b3%ef%bc%89","status":"publish","type":"post","link":"https:\/\/kokoro-hino.tokyo\/?p=814","title":{"rendered":"\u30e9\u30c4\u30fc\u30c0\uff08\u30eb\u30e9\u30b7\u30c9\u30f3\uff09"},"content":{"rendered":"

\u4f4f\u53cb\u88fd\u85ac\uff08\u73fe\uff1a\u5927\u65e5\u672c\u4f4f\u53cb\u88fd\u85ac\uff09\u304c\u5275\u88fd\u3057\u3001\u5e74\u95932000\u5104\u5186\u3092\u58f2\u308a\u4e0a\u3052\u308b\u30d6\u30ed\u30c3\u30af\u30d0\u30b9\u30bf\u30fc\u3001\u300c\u30e9\u30c4\u30fc\u30c0<\/strong><\/span>\u300d\u304c6\u6708\u306b\u672c\u90a6\u3067\u3082\u767a\u58f2\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3001\u30e9\u30c4\u30fc\u30c0\u3092\u6982\u89b3\u3057\u3066\u307f\u307e\u3059\u3002<\/p>\n

\u307e\u305a\u306f\u3001\u7279\u5fb4\u3092\u308f\u304b\u308a\u3084\u3059\u304f\u7b87\u6761\u66f8\u304d\u3067\u7f85\u5217\u3057\u3066\u307f\u307e\u3059\u3002<\/p>\n

\u53cc\u6975\u6027\u969c\u5bb3\u306b\u304a\u3051\u308b\u3046\u3064\u75c7\u72b6\u306e\u6539\u5584\u306b\u9069\u5fdc\u3092\u6301\u3064\u30013\u756a\u76ee\u306e\u6297\u7cbe\u795e\u75c5\u85ac\u3067\u3042\u308b\u3002\uff08\u4ed62\u5264\u306f\u3001\u30aa\u30e9\u30f3\u30b6\u30d4\u30f3\u3068\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\uff09<\/p>\n

\u4f53\u91cd\u5897\u52a0\u306b\u5bfe\u3057\u3066\u4e2d\u7acb\u3067\u3042\u308b\u3002\uff08\u4f53\u91cd\u5897\u52a0\u304c\u5c11\u306a\u3044\uff09<\/p>\n

\u8102\u8cea\u4ee3\u8b1d\u306b\u5bfe\u3057\u3066\u4e2d\u7acb\u3067\u3042\u308b\u3002\uff08\u8102\u8cea\u7570\u5e38\u304c\u5c11\u306a\u3044\uff09<\/p>\n

\u7cd6\u4ee3\u8b1d\u306b\u5bfe\u3057\u3066\u4e2d\u7acb\u3067\u3042\u308b\u3002\uff08\u7cd6\u5c3f\u75c5\u306e\u4eba\u306b\u3082\u4f7f\u3048\u308b\uff09<\/p>\n

\u93ae\u9759\u304c\u5c11\u306a\u3044\u3002<\/p>\n

QT\u5ef6\u9577\u306a\u3069\u306e\u5fc3\u96fb\u56f3\u7570\u5e38\u3092\u8a8d\u3081\u306a\u3044\u3002<\/p>\n

\u30bb\u30ed\u30c8\u30cb\u30f35-HT7\u53d7\u5bb9\u4f53\u906e\u65ad\u4f5c\u7528\u306b\u3088\u308a\u3001\u8a8d\u77e5\u6a5f\u80fd\u6539\u5584\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n

\u30d2\u30b9\u30bf\u30df\u30f3\uff281\u3001\u30e0\u30b9\u30ab\u30ea\u30f3\uff2d\uff11\u53d7\u5bb9\u4f53\u306b\u5bfe\u3059\u308b\u89aa\u548c\u6027\u304c\u6b86\u3069\u7121\u304f\u3001\u93ae\u9759\u3084\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3002<\/p>\n

\u5f31\u3044\u306a\u304c\u3089\u03b12\uff21\u62ee\u6297\u4f5c\u7528\u3092\u6709\u3057\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u5206\u6ccc\u3092\u5897\u3084\u3059\u3002<\/p>\n

\u30a2\u30b8\u30a2\u4eba\u306f\u767d\u4eba\u306b\u6bd4\u3079\u3066\u30eb\u30e9\u30b7\u30c9\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u304c\u308a\u3084\u3059\u3044\u3002<\/p>\n

\u6700\u3082\u4e00\u822c\u7684\u306b\u898b\u3089\u308c\u308b\u526f\u4f5c\u7528\u306f\u3001\u30a2\u30ab\u30b7\u30b8\u30a2\u3001\u5410\u304d\u6c17\u3001\u50be\u7720\u3001\u30b8\u30b9\u30c8\u30cb\u30a2\u306a\u3069\u3067\u3042\u308b\u3002<\/p>\n

\u7a7a\u8179\u6642\u3092\u907f\u3051\u3066\u3001\u98df\u5f8c\u306b\u670d\u7528\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002<\/p>\n

\u526f\u4f5c\u7528\u306e\u767a\u73fe\u306f\u3001\u5915\u65b9\u4ee5\u964d\u306b\u98df\u5f8c\u670d\u85ac\u3059\u308b\u3068\u8d77\u3053\u308a\u306b\u304f\u3044\u3002<\/p>\n

 <\/p>\n

\n

\u4ee5\u4e0b\u306f\u672c\u5264\u306e\u6982\u7565\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u4e00\u822c\u540d\u306f\u300c\u30eb\u30e9\u30b7\u30c9\u30f3<\/span>\u5869\u9178\u5869\u300d\uff08Lurasidone Hydrochloride\uff09\u3067\u3059\u3002<\/p>\n

\u5206\u985e\u306f\u3001\u975e\u5b9a\u578b\u6297\u7cbe\u795e\u75c5\u85ac\u30fbSDA\uff08serotonin-dopamine antagonist\uff09\u30fb\u7b2c\u4e8c\u4e16\u4ee3\u6297\u7cbe\u795e\u75c5\u85ac<\/span>\u3001\u306b\u533a\u5206\u3055\u308c\u307e\u3059\u304c\u3001\u6f5c\u5728\u7684\u306b\u6c17\u5206\u5b89\u5b9a\u52b9\u679c\u3082\u6709\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u69cb\u9020\u5f0f
\n\"\"<\/p>\n

\"\"<\/p>\n

 <\/p>\n

\u4fdd\u967a\u9069\u5fdc\uff08\u52b9\u80fd\u53c8\u306f\u52b9\u679c\uff09<\/strong><\/span>\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002
\n\u7d71\u5408\u5931\u8abf\u75c7
\n\u53cc\u6975\u6027\u969c\u5bb3\u306b\u304a\u3051\u308b\u3046\u3064\u75c7\u72b6\u306e\u6539\u5584<\/p>\n

\u7528\u6cd5\u53ca\u3073\u7528\u91cf<\/span><\/strong>\u306f\u3001
\n\u7d71\u5408\u5931\u8abf\u75c7\u3067\u306f\u30011\u65e51\u56de40mg\u3092\u98df\u5f8c\u306b\u670d\u7528\uff08\u6700\u592780mg\uff09
\n\u53cc\u6975\u6027\u969c\u5bb3\u306b\u304a\u3051\u308b\u3046\u3064\u75c7\u72b6\u306e\u6539\u5584\u3067\u306f\u30011\u65e51\u56de20\uff5e60mg\u3092\u98df\u5f8c\u306b\u670d\u7528\uff08\u521d\u671f\u91cf20mg\u3001\u6700\u592760mg\uff09
\n\uff08\u30e9\u30c4\u30fc\u30c0\u306f\u3001\u7a7a\u8179\u6642\u3088\u308a\u3082\u98df\u5f8c\u6295\u4e0e\u306e\u65b9\u304c\u8840\u6e05\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059<\/span><\/strong>\u3002\uff09<\/p>\n

\u4e00\u822c\u7684\u306a\u670d\u7528\u3067\u306e\u6ce8\u610f\u70b9\u30922\u70b9\u793a\u3057\u307e\u3059
\n\u98df\u5f8c\u306b\u670d\u7528\u3059\u308b\u3053\u3068<\/strong><\/span>
\n\uff08\u5438\u53ce\u304c\u98df\u4e8b\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u304f\u3001\u7a7a\u8179\u6642\u6295\u4e0e\u3067\u306f\u5438\u53ce\u304c\u4f4e\u304f\u306a\u308b\uff09
\n\u81ea\u52d5\u8eca\u306e\u904b\u8ee2\u7b49\u5371\u967a\u3092\u4f34\u3046\u6a5f\u68b0\u306e\u64cd\u4f5c\u306b\u5f93\u4e8b\u3057\u306a\u3044\u3053\u3068<\/strong><\/span>
\n\uff08\u7720\u6c17\u3001\u6ce8\u610f\u529b\u30fb\u96c6\u4e2d\u529b\u30fb\u53cd\u5c04\u904b\u52d5\u80fd\u529b\u7b49\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\uff09<\/p>\n

\u526f\u4f5c\u7528<\/span><\/strong><\/span>
\n\u5b89\u5168\u6027\u8a55\u4fa1\u5bfe\u8c61\u4f8b\u6570 876\u4f8b\uff08\u7d71\u5408\u5931\u8abf\u75c7692\u4f8b\u3001\u53cc\u6975\u6027\u969c\u5bb3184\u4f8b\uff09\u3067\u898b\u3089\u308c\u305f\u4e3b\u306a\u526f\u4f5c\u7528\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\u3002<\/p>\n

\u30a2\u30ab\u30b7\u30b8\u30a2\uff08\u9759\u5750\u4e0d\u80fd\uff09\u30008.6%<\/span><\/strong><\/span>
\n\u60aa\u5fc3\u30004.6%<\/strong><\/span>
\n\u50be\u7720\u30003.2%<\/strong><\/span>
\n\u982d\u75db\u30002.9%<\/strong><\/span>
\n\u4e0d\u7720\u75c7\u30002.9%
\n\u5614\u5410\u30002.4%
\n\u4fbf\u79d8\u30002.2%
\n\u632f\u6226\u30002.1%
\n\u4e0d\u5b89\u30002.1%<\/p>\n

\u85ac\u7269\u52d5\u614b<\/span><\/strong><\/span>\uff08\u5358\u56de\u6295\u4e0e\uff09
\n\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u306b1.5\u6642\u9593<\/strong>\u304b\u304b\u308a\u307e\u3059\u3002
\n\u98df\u5f8c\u6295\u4e0e\u306e\u5834\u5408\u306e\u534a\u6e1b\u671f\u306f22\u6642\u9593<\/strong><\/span>\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u4ee3\u8b1d<\/span><\/strong><\/span>
\n\u4e3b\u306b CYP3A4 \u306b\u3088\u308b\u4ee3\u8b1d\u3092\u53d7\u3051\u3066\u4f53\u5185\u304b\u3089\u6d88\u5931\u3057\u307e\u3059\u3002
\n\u307e\u305f\u81e8\u5e8a\u3067\u4f7f\u308f\u308c\u308b\u7528\u91cf\u3067\u306f\u3001 CYP \u9175\u7d20\u3092\u963b\u5bb3\u3057\u307e\u305b\u3093\u3002<\/p>\n

CYP3A4\u306b\u3088\u308b\u4ee3\u8b1d\u3092\u53d7\u3051\u308b\u3053\u3068\u304b\u3089\u3001CYP3A4\u3092\u5f37\u304f\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3001\u9006\u306b\u5f37\u304f\u8a98\u5c0e\u3059\u308b\u85ac\u5264\u3068\u306e\u4f75\u7528\u306f\u7981\u5fcc<\/strong><\/span>\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u7981\u5fcc\u3068\u306a\u3063\u3066\u3044\u308b\u85ac\u5264\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n

\u5f37\u304f\u963b\u5bb3\u3059\u308b\u305f\u3081\u7981\u5fcc\u3068\u306a\u3063\u3066\u3044\u308b\u85ac\u5264\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u8840\u4e2d\u6fc3\u5ea6\u4e0a\u6607\uff09\uff1a<\/strong><\/span>
\n\u30a2\u30be\u30fc\u30eb\u7cfb\u6297\u771f\u83cc\u5264\uff08\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\u3001\u30df\u30b3\u30ca\u30be\u30fc\u30eb<\/strong><\/span>\u306a\u3069\uff09
\nHIV \u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u963b\u5bb3\u5264
\n\u30b3\u30d3\u30b7\u30b9\u30bf\u30c3\u30c8\u3092\u542b\u3080\u88fd\u5264
\n\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3<\/strong><\/span><\/p>\n

\u5f37\u304f\u8a98\u5c0e\u3059\u308b\u305f\u3081\u7981\u5fcc\u3068\u306a\u3063\u3066\u3044\u308b\u85ac\u5264\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u8840\u4e2d\u6fc3\u5ea6\u4f4e\u4e0b\uff09\uff1a<\/strong><\/span>
\n\u30ea\u30d5\u30a1\u30f3\u30d4\u30b7\u30f3
\n\u30d5\u30a7\u30cb\u30c8\u30a4\u30f3<\/p>\n

CYP3A4 \u306b\u95a2\u9023\u3057\u3001\u4ee5\u4e0b\u306e\u85ac\u5264\u7b49\u306f\u4f75\u7528\u6642\u306b\u6ce8\u610f\u304c\u5fc5\u8981<\/strong>\u3067\u3059\u3002
\n\u30b8\u30eb\u30c1\u30a2\u30bc\u30e0\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4e0a\u6607\uff09<\/strong><\/span>
\n\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4e0a\u6607\uff09<\/span><\/strong>
\n\u30d9\u30e9\u30d1\u30df\u30eb\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4e0a\u6607\uff09
\n\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u542b\u6709\u98df\u54c1\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4e0a\u6607\uff09<\/span><\/strong>
\n\u30ab\u30eb\u30d0\u30de\u30bc\u30d4\u30f3\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4f4e\u4e0b\uff09<\/span><\/strong>
\n\u30d0\u30eb\u30d3\u30c4\u30fc\u30eb\u9178\u8a98\u5c0e\u4f53\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4f4e\u4e0b\uff09
\n\u30bb\u30f3\u30c8\u30fb\u30b8\u30e7\u30fc\u30f3\u30ba\u30fb\u30ef\u30fc\u30c8\u542b\u6709\u98df\u54c1\uff08\u30e9\u30c4\u30fc\u30c0\u306e\u6fc3\u5ea6\u4f4e\u4e0b\uff09<\/strong><\/span><\/p>\n

\u307e\u305f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb<\/span><\/strong>\u306f\u4e2d\u67a2\u6291\u5236\u4f5c\u7528\u3092\u6709\u3059\u308b\u306e\u3067\u3001\u4f75\u7528\u306b\u3088\u308a\u30e9\u30c4\u30fc\u30c0\u306e\u4e2d\u67a2\u795e\u7d4c\u6291\u5236\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n

 <\/p>\n

\u53d7\u5bb9\u4f53\u7d50\u5408\u89aa\u548c\u6027<\/span><\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u53d7\u5bb9\u4f53<\/td>\n\u89aa\u548c\u6027 Ki\uff08nmol\/L\uff09<\/td>\n\u5099\u8003<\/td>\n<\/tr>\n
5-HT 2A<\/td>\n0.357\u30010.470<\/td>\n\u30c9\u30d1\u30df\u30f3\u904a\u96e2\u2191<\/td>\n<\/tr>\n
5-HT 7<\/td>\n0.495<\/td>\n\u9670\u6027\u75c7\u72b6\u6539\u5584\u3001\u6c17\u5206\u30fb\u7761\u7720\u30fb\u8a8d\u77e5\u6a5f\u80fd\u6539\u5584<\/td>\n<\/tr>\n
\u30c9\u30d1\u30df\u30f3 D 2L<\/td>\n0.994<\/td>\n<\/td>\n<\/tr>\n
\u30c9\u30d1\u30df\u30f3 D 2<\/td>\n1.68<\/td>\n\u967d\u6027\u75c7\u72b6\u306e\u8efd\u6e1b\u3001\u6c17\u5206\u5b89\u5b9a<\/td>\n<\/tr>\n
5-HT 1A<\/td>\n6.38<\/td>\n<\/td>\n<\/tr>\n
\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u03b1 2C<\/td>\n10.8<\/td>\n<\/td>\n<\/tr>\n
\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u03b1 2A<\/td>\n40.7<\/td>\n<\/td>\n<\/tr>\n
\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u03b1 1<\/td>\n47.9<\/td>\n<\/td>\n<\/tr>\n
5-HT 2C<\/td>\n415<\/td>\n<\/td>\n<\/tr>\n
\u30d2\u30b9\u30bf\u30df\u30f3 H 1<\/td>\n>1000<\/td>\n<\/td>\n<\/tr>\n
\u30e0\u30b9\u30ab\u30ea\u30f3M 1<\/td>\n>1000<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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